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Cat Number: API53861

Indomethacin

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CAS Number

53-86-1

Description

Indomethacin is an inhibitor of Cox-1 and activator of PPARγ

MolecularWeight

357.8

MolecularFormula

C19H16ClNO4

Solubility

Soluble in methanol, ethanol (20 mg/ml), ether, acetone (40 mg/ml), chloroform (50 mg/ml), DMSO (100 mM), castor oil, water (0.94 mg/l), 0.1 M Na2CO3 (~0.1 mg/ml), and DMF&DMSO (~17.5 mg/ml).

Storage

Store at room temperature

MeltingPoint

155℃

BoilingPoint

~499.4℃ at 760 mmHg

Density

~1.3 g/cm³

RefractiveIndex

1.62

IC50

COX-1: IC50 = 0.1 µM (ovine); COX-2: IC50 = 6 µM (ovine); phospholipase A2: IC50 = 145 µM; COX-1: IC50 = 1.67 µM (human); COX-2: IC50 = 24.6 µM (human)

pKValue

pKa: 4.5, 4.17

PreparationUse

anti-inflammatory drug

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